Yes, you could replace your HD with a SSD as long as the SSD is able to run at SATA II (3.0 Gb/s).
You may want to think about how much stuff you plan to store on your drive. SSD's tend to be expensive as you go to larger sizes.
You may want to concider going with a SSHD which is a hybrid drive (SSD and HD in one device). The SSD acts as a deep cache to give you the speed, and the HD offers deep storage space - The best of both!
Seagate make a nice one, here's the product page: Seagate Laptop SSHD. These drives also have auto SATA port speed detection so it will work in your system.
Here's the needed steps to open your system to get to the drive: Asus Eee PC 1215N Hard Drive Replacement
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